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Fertility Health
Taking folic acid before pregnancy has various benefits for your baby. This article by Theralogix, explores various genetic defects that supplementation with folic acid can help prevent.

The CDC and the U.S. Public Health Service recommend that all women between the ages of 15 and 49 take 400 micrograms (mcg) of folic acid a day. Taking folate before pregnancy provides various health benefits for both mom and baby.

This article discusses what folate is and shares some of the major benefits of folate before pregnancy.

About Folic Acid

Folic acid or folate (more on the difference between the two in a bit) is a water-soluble B vitamin. Folate is vitamin B9, to be exact. Our bodies need it to make DNA, and it is essential for cell division.

Folic Acid vs. Folate

You often hear the terms “folic acid” and “folate” used interchangeably, which can sometimes cause confusion. “Folate” is a generic term referring to both natural folate in foods, as well as folic acid and other types of folate found in dietary supplements (such as methylated folate).

Natural Folate

Certain foods like lentils, chickpeas, asparagus, and spinach contain natural folate. Whole food is the only source of natural folate. Likewise, there are no naturally occurring food sources of folic acid.

In general, getting nutrients from foods is preferred to getting them from supplements. However, there may be some differences of opinion when it comes to folate.

Carolyn Gundell, M.S., Fertility Nutritionist from Reproductive Medicine Associates of Connecticut, provides a gentle reminder that folate from foods may not completely replace folate from supplements. The body can only partially absorb naturally occurring folate (50-60%). Also, cooking folate-rich foods destroys as much as 50-90% of the folate found within them.

It is a good idea to make sure you balance your diet with healthy, natural sources of folate as well as a moderate amount of folic acid (or methylated folate) from supplements.

Folic Acid

Folic acid is the synthetic form of folate commonly found in dietary supplements and fortified foods.  

Beginning in 1998, the USDA required food manufacturers to add folic acid to certain food products that did not naturally contain folate, including enriched bread, flour, cornmeal, rice, pasta, and other grain products.

You may also find folic acid in multivitamins or other dietary supplements, but it’s not the only form of supplemental folate anymore. Many products offer methylated folate instead.

Methylated Folate

When a person consumes folic acid, the body converts it to the metabolically active form called methylated folate (or L-methylfolate). While this form contains the word “folate,” it is not the same as naturally occurring folate. 

Some women have a genetic defect (called MTHFR polymorphism), which makes it hard for them to convert folic acid to the active form that their bodies can use. This congenital disability does not prevent those with the defect from activating folic acid; it just reduces their ability to do so efficiently. 

About 20-50% of the population have one copy of the defective gene, reducing the capacity to activate folic acid by about 30%. A much smaller percentage of the population (3-30%) have two copies of the defective gene, which reduces the ability to activate folic acid by about 65%. 

Some preconception prenatal vitamins contain the active form of folic acid (methylated folate). Using methylated folate helps ensure that women with the genetic defect absorb the right amount of folate to prepare for pregnancy. The formation of the neural tube occurs very early in pregnancy, so the most critical time to take methylated folate is while trying to conceive and during early pregnancy.

Benefits of Folate Before Pregnancy

Now that we know about the different folate types, we can answer the question – what are some of the benefits of taking folate before pregnancy? 

Folate helps with many of the body’s normal processes. There is a strong connection between adequate folate intake and healthy neural tube development. The neural tube later becomes the central nervous system, including the brain and spinal cord. Healthful diets with adequate folate may reduce a woman’s risk of having a child with a brain or spinal cord birth defect.

Spina Bifida

The most common NTD is spina bifida. When a baby has spina bifida, the tiny bones that make up the vertebrae do not close completely, and the spinal cord pokes through the spine.

Spina bifida affects roughly 1,500 babies in the United States each year. Health consequences of spina bifida can include paralysis in the legs and difficulty controlling the bladder or bowel. In some cases, doctors can treat spina bifida with surgery before or after birth.


One of the more severe NTDs is anencephaly. When the upper part of the neural tube that forms the brain does not close completely, a baby can develop anencephaly.

Approximately 1,000 babies are born with anencephaly in the United States each year. Children with this NTD are missing major parts of their brain, skull, and scalp. Survival rates are low, and babies born with anencephaly can typically only survive for a few hours after birth.


Encephalocele is another NTD affecting roughly 375 babies in the United States each year. This NTD occurs when the sac that contains the membranes that cover the brain (and often a part of the brain, as well) pokes through an opening in the skull.

Babies with encephalocele usually require surgery to place parts of the brain back into the skull and close the opening. If there is a buildup of fluid in the brain, the baby will need to drain the excess fluid. The outlook for babies born with encephalocele depends on the location of the opening, the parts of the brain affected, and whether they have other birth defects. More often than not, a child with encephalocele will face some challenges, including intellectual disability, movement problems or paralysis, vision problems, or seizures.

Recommended Timing for Folate Before Pregnancy

The neural tube closes around the fourth week of pregnancy, so it is important to start taking a supplement with folate at least one month before conception, continuing throughout pregnancy. 

Because the neural tube closes before many women even know they are pregnant, women of childbearing age need to get enough folate even if they are not planning a pregnancy. According to the Centers for Disease Control (CDC), roughly 45% of all pregnancies in the United States are unplanned.

The most important takeaway is that folate is beneficial for any woman who may become pregnant. 

If this is you, make sure you take a women’s multivitamin or preconception prenatal vitamin with the right amount of folic acid or methylated folate. 

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